Calcium Enzymes are Important for Healing Injuries

Thanks partly to the way in which the message has been put across in various formats for decades, people are acutely aware of the importance of calcium in helping to develop bones that are not only healthy, but also strong. This in itself does make a difference when it comes to general health, but there are other issues to take into consideration when looking at the role calcium plays on a cellular level with these considerations often being overlooked by chiropractors.

Principle_of_calcium_encoding_Author Maurizio De Pitta_Calcium EnzymesThe Importance Of Calcium Enzymes in the healing of the body

On this level there are two calcium enzymes, called Sarcoplasmic Reticulum Ca2+ ATPase, or SERCA for short, and Plasma Membrane CA2+ ATPase, or PMCA for short, that play a key role in both the concentration and location of the calcium ion in the cells. The roles of these calcium enzymes are so important that they do play a major part in the health of patients, so a better understanding of them will be advantageous to ensure that superior treatment is offered.


First, we should look more closely at SERCA. This particular enzyme is often seen as being the most important of the two when a patient is suffering from subluxation. In short, after the contraction of muscle fibres takes place, a calcium ion is released to the cytoplasm from the sarcoplasmic reticulum, herein referred to as SR. The role that this plays is to relax the muscle fibre and to return it to its original state to then allow it to contract again in the future. However, what happens when there are not enough of these calcium enzymes being produced is that the muscle becomes tired and eventually this will lead to it becoming permanently locked resulting in pain and the patient being uncomfortable.

This problem does appear to have a major impact those muscles that both strengthen and support the spine with particular reference being made in studies to areas such as interspinales, intertransversaii, rotatores, and those larger multifidus. Clearly there are also times where this type of fatigue leading to the locking of the muscle may also be beneficial in helping to prevent further damage, but in most cases the focus must be on helping to increase the production of SERCA to not only release the muscles, but to reduce the pain being felt by the patient.


Every single cell that is in the body contains PMCA and indeed this is the enzyme that is responsible for regulating the level of calcium ions that appear in all of those cells. When a problem develops with the production of PMCA it can, in turn, lead to too many calcium ions being present with this itself resulting in a number of health issues developing including cell damage. By increasing the level of PMCA in the cell it will then lead to the general health of the cell resulting in quicker healing times for soft tissue injuries with this being seen as an important breakthrough mainly for people with different spinal injuries.

Studies have shown that the production of PMCA reduces in those people that have had a spinal cord injury resulting in more swelling in and around the cells, more immunoreactive cells being produced, and greater neuronal damage in the spinal cord itself. As these levels drop it does then increase the chances of what is seen as a secondary spinal cord injury developing, so increasing the levels of PMCA is of paramount importance for the health of the patient.

Calcium and inflammation

Calcium in our cells has a direct impact on how our body deals with inflammation. In short, inflammation occurs when certain reactions take place including the production of histamine and leukotreines and their production is triggered by the levels of inter-cellular calcium exceeding normal levels. In order to reduce inflammation it is, therefore, important that the levels of both SERCA and PMCA remain constant as any reduction in them can lead to an increase in the pain and swelling suffered by the patient. Indeed, this is what actually occurs in the body when a patient is injected with steroids to tackle the inflammation and acupuncture has also been shown to work in the same way. As an interesting aside, certain natural products such as ginger tea and astragalus have also been shown to increase the production of SERCA and the use of them is certainly an interesting point to take into consideration.

CA2+ATPase deficiencies

Next, we need to look at how you can identify that there is indeed a problem with the production of this calcium enzyme as being able to identify the issue is key to ensuring patients get the correct treatment as soon as possible.

The easiest way to identify the problem is due to the simple fact that if they are there with some form of injury, then they are suffering from a deficiency in this enzyme at least in the area that is injured and in particular within the soft tissues. There are, however, other reasons for a reduction in the levels of these calcium enzymes including getting older, the way they lead their life, and even toxins that appear in the air and it is worth taking a few minutes to look at how these factors do indeed make a difference.


Studies have shown that as we age our body starts to produce lower amount of various hormones and calcium enzymes that have contributed to keeping us healthy with our cells bearing the brunt of this change to our bodies. The main areas that are then affected by this include our muscles becoming weaker, suffering from fatigue quicker than before, being unable to recover from physical exertion or injuries the same way as before, suffering from more niggles and pains, and even issues such as being unable to sleep as well can be contributed to these calcium enzymes. It does, therefore, make sense that an improvement in their levels can indeed make a difference to health not just now, but for the future as well.


Our lifestyle will also have an impact on the production levels of calcium enzymes as smoking, alcohol, drugs, and even stress will all make a difference and reduce the amount of the calcium enzymes that are being produced. This is purely down to how our body deals with these issues, but there is no doubt that if you are less stressed and look after your body and are careful about what you put into it, then it will make a difference with the production of CA2+ATPase.


Our body absorbs various toxins throughout the day and it has been shown that elements such as mercury, fluoride, chemicals used in pesticides, smoke, and naturally occurring radiation can all inhibit the production of these calcium enzymes. However, perhaps the most surprising part is that even food additives and flavorings can have a negative impact.

How a reduction in CA2+ATPase makes a difference

Apart from it clearly having an impact on our muscles and ability to sleep as well as we should, it has also been shown that a reduction in levels of this enzyme can also play a role in developing health issues such as asthma, diabetes, and even heart disease. This does mean that a greater understanding as to the importance of this enzyme is essential not only for those people with muscle injuries, but for general health amongst the population.

To conclude, when dealing with any kind of injury to the body, you need to be aware of the importance of the CA2+ATPase calcium enzymes. By doing so it will lead to better care options and better recovery times.